Prof. Mazzone (2010)

Project details

Project start: 
2010
Pathology: 
Colorectal Cancer
University: 
Katholieke Universiteit Leuven (KU Leuven)

Goal

To develop a test to diagnose and predict colorectal cancer with high specificity.

Why ?

The prognosis (outlook) and chance of cure are much better if colorectal cancer (CRC, cancer of the colon or rectum) is detected at an early stage rather than at a later stage.

Scientific project description

 “Monomark” is a test based on gene expression in monocytes. The test is able to diagnose CRC at very early stages and can be used for disease follow-up and relapse monitoring.

Key findings

A first verification study in 4 centers confirmed the signature following a 3 step monocyte isolation procedure.

The team then switched to a one-step-monocyte isolation procedure (monocyte capturing + qPCR) and is currently verifying promising preliminary observations in healthy volunteers, patients with hyperplastic polyps, patients with adenomatous polyps and patients with CRC.

Status

    • IP has been secured
    • Publication in preparation
    • Looking for an industry partner to start prospective clinical validation studies

Budget

Committed/spent: €495.000/€460.800

 

Discovery
Qualification & Verification
Platform selection & Clinical Assay
Validation
Prof. Mazzone (2010)
Colorectal Cancer
monocytes