Project detailsProject start:2010Pathology:Colorectal CancerUniversity:Katholieke Universiteit Leuven (KU Leuven)
To develop a test to diagnose and predict colorectal cancer with high specificity.
The prognosis (outlook) and chance of cure are much better if colorectal cancer (CRC, cancer of the colon or rectum) is detected at an early stage rather than at a later stage.
Scientific project description
“Monomark” is a test based on gene expression in monocytes. The test is able to diagnose CRC at very early stages and can be used for disease follow-up and relapse monitoring.
A first verification study in 4 centers confirmed the signature following a 3 step monocyte isolation procedure.
The team then switched to a one-step-monocyte isolation procedure (monocyte capturing + qPCR) and is currently verifying promising preliminary observations in healthy volunteers, patients with hyperplastic polyps, patients with adenomatous polyps and patients with CRC.
- IP has been secured
- Publication in preparation
- Looking for an industry partner to start prospective clinical validation studies