Project detailsProject start:2008Pathology:Brain CancerUniversity:Vrije universiteit Brussel (VUB)
Prognostic test for glioblastoma.
Glioblastoma is the most frequent brain cancer in adulthood, but still a rare disease.
It is a heterogenous tumor composed from tumor cells and a small portion of cancer stem cells - tumor-initiating cells, which may be a cause of their resistance to conventional treatments and high reoccurrence rate.
Scientific project description
Specific antibodies (nanobodies) against a marker (CD133) expressed by glioblastoma-derived cancer stem cells have been produced on the lab scale with a confirmed process. A protocol has been established to apply the nanobodies and staining of tumor tissue will be used to predict the course/outcome of glioblastoma patients and to adapt treatment in function thereof.
- Project ended