Prof. Leyns (2008)

Project details

Project start: 
2008
Pathology: 
Brain Cancer
University: 
Vrije universiteit Brussel (VUB)

Goal

Prognostic test for glioblastoma.

Why ?

Glioblastoma is the most frequent brain cancer in adulthood, but still a rare disease.
It is a heterogenous tumor composed from tumor cells and a small portion of cancer stem cells - tumor-initiating cells, which may be a cause of their resistance to conventional treatments and high reoccurrence rate.

Scientific project description

Specific antibodies (nanobodies) against a marker (CD133) expressed by glioblastoma-derived cancer stem cells have been produced on the lab scale with a confirmed process. A protocol has been established to apply the nanobodies and staining of tumor tissue will be used to predict the course/outcome of glioblastoma patients and to adapt treatment in function thereof.

Status

  • Project ended

Budget

Committed/spent: €368.500/€368.500

 

Discovery
Qualification & Verification
Platform selection & Clinical Assay
Validation