Prof. Gallez (2012)

Project details

Project start: 
2012
Pathology: 
Brain Cancer
Head and neck Cancer
University: 
Université Catholique de Louvain (UCL)

Goal

Hypoxia evaluation for tailoring drugs and irradiation protocols in brain and head & neck tumors.

Why ?

Tumor hypoxia, the situation where tumor cells have been deprived of oxygen, promotes the emergence of metastases and regeneration of blood vessels and makes the tumor less sensitive to treatments, especially to radiotherapy.
This is esp. problematic in solid tumors such as brain and head & neck tumors.

Scientific project description

A new non‐invasive Magnetic Resonance Imaging (MRI) method allowing rapid mapping of changes in tissue oxygenation. This sequence with the acronym MOBILE (Mapping of Oxygen By Imaging Lipids relaxation Enhancement), has high potential for translation into daily clinical practice because it enables non‐invasive imaging of changes in tumor oxygenation. The primary aim of the present project is to qualify this new method as a reliable biomarker of tumor oxygenation and to translate into the clinical practice (prediction of chemo/radio sensitivity).

Key findings

  • Preclinical studies: data have been obtained demonstrating the applicability of MOBILE on three tumor models.
  • Clinical studies: obtained MOBILE images in 16 patients with HN tumors and in 31 patients with gliomas.

Status

    • IP secured on the technology platform;  a trade mark for MOBILE  has been applied for
    • 2 papers published on the method/sequence
    • A publication is in preparation on the gliomas study
    • Validation study in preparation
    • Co-funding secured from the Cancer Plan

Budget

Committed/spent: €192.106/€ 80.314

 

Discovery
Qualification & Verification
Platform selection & Clinical Assay
Validation
Prof. Gallez (2012)
Brain Cancer, Head and neck Cancer
imaging